The study of 9,10-dihydroacridine derivatives as a new and effective molecular scaffold for antibacterial agent development

The emergence of worldwide spreading drug-resistant bacteria has been a serious threat to public health during the past decades. The development of new and effective antibacterial agents to address this critical issue is an urgent action. In the present study, we investigated the antibacterial activity of two 9,10-dihydroacridine derivatives and their mechanism. Both compounds were found possessing strong antibacterial activity against some selected Gram-positive bacteria including MRSA, VISA and VRE. The biological study suggests that the compounds promoted FtsZ polymerization and also disrupted Z-ring formation at the dividing site and consequently, the bacterial cell division is interrupted and causing cell death. (c) 2021 Elsevier Inc. All rights reserved.

Automated summary

The study revealed that two 9,10-dihydroacridine derivatives have strong antibacterial activity against selected Gram-positive bacteria by promoting FtsZ polymerization and disrupting Z-ring formation, leading to bacterial cell division interruption and cell death.