期刊
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
卷 17, 期 -, 页码 293-318出版社
BEILSTEIN-INSTITUT
DOI: 10.3762/bjoc.17.28
关键词
biotransformation; chemical biology; fluorine; F-19 NMR; probes; protein structure
资金
- Biotechnology and Biological Sciences Research council [BB/P022189/1]
- Science Foundation Ireland [17/BBSRC/3417]
- BBSRC [BB/P022189/1] Funding Source: UKRI
- Science Foundation Ireland (SFI) [17/BBSRC/3417] Funding Source: Science Foundation Ireland (SFI)
F-19 NMR is widely used in the field of chemical biology for synthesizing new fluorinated probes, monitoring protein interactions, structural analysis, etc. It remains relevant for investigating the biosynthesis and biodegradation of fluorinated organic compounds.
We previously reviewed the use of F-19 NMR in the broad field of chemical biology [Cobb, S. L.; Murphy, C. D. J. Fluorine Chem. 2009, 130, 132-140] and present here a summary of the literature from the last decade that has the technique as the central method of analysis. The topics covered include the synthesis of new fluorinated probes and their incorporation into macromolecules, the application of F-19 NMR to monitor protein-protein interactions, protein-ligand interactions, physiologically relevant ions and in the structural analysis of proteins and nucleic acids. The continued relevance of the technique to investigate biosynthesis and biodegradation of fluorinated organic compounds is also described.
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