期刊
BEHAVIOURAL BRAIN RESEARCH
卷 401, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.bbr.2020.113093
关键词
Serotonin; 5-HT2A; 5-HT2C; Marble burying; Psilocybin; Compulsivity
资金
- Lundbeckfonden [R2632017-3000]
This study confirmed that psychedelics acting as 5-HT2AR agonists can reduce compulsive-like digging behavior in mice, while also suggesting that both 5-HT2A and 5-HT(2C)Rs may work in parallel on this behavior. Results with psilocybin indicate that a 5-HT2R-independent mechanism may also contribute to its effect on repetitive digging behavior.
Psychedelic drugs acting as 5-hydroxyptryptamine 2A receptor (5-HT2AR) agonists have shown promise as viable treatments of psychiatric disorders, including obsessive-compulsive disorder. The marble burying test is a test of compulsive-like behavior in mice, and psychedelics acting as 5-HT2AR agonists can reduce digging in this test. We assessed the 5-HT2R contribution to the mechanisms of two 5-HT2A agonists on digging behavior in female NMRI mice, using citalopram as a reference compound. While the 5-HT2AR antagonist M100907 blocked the effect of DOI and the 5-HT2CR antagonist SB242084 blocked the effect of citalopram, neither antagonist blocked the effect of psilocybin. This study confirms 5-HT2AR agonism as a mechanism for reduced compulsive-like digging in the MB test and suggests that 5-HT2A and 5-HT(2C)Rs can work in parallel on this type of behavior. Our results with psilocybin suggest that a 5-HT2R-independent mechanism also contributes to the effect of psilocybin on repetitive digging behavior.
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