期刊
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
卷 41, 期 4, 页码 1284-1290出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/ATVBAHA.120.314211
关键词
hematopoiesis; homeostasis; immunity; macrophages; metabolism
资金
- NovoNordisk Foundation award Metabolite-related inflammation in diabetes spectrum diseases: MeRIAD [NNF 0064142]
- British Heart Foundation Centre for Research Excellence, Oxford
- NIHR Biomedical Research Centre, Oxford
Physiological functions are intricately intertwined, with evidence from immunometabolism field showing that cells can be programmed by changes in metabolic environment through epigenetic modifications, causing persistent changes. Understanding these processes can have significant implications for the diagnosis and treatment of diabetes and related metabolic states.
Accumulating evidence shows how diverse physiological functions, such as metabolism, immunity, tissue homeostasis, and hematopoiesis, are intricately and profoundly intertwined at multiple levels. This brief review will present evidence from a rapidly expanding field of immunometabolism, highlighting how cells that are relevant to processes at play in determining vascular health and disease can be programmed by changes in their metabolic environment. It will focus on how such changes can be imprinted or trained, particularly through epigenetic modifications, such that adaptations driven by metabolic signals can cause persistent changes in cell function, even after the original stimulus has been corrected or removed. Recognition of these processes and elucidation of the mechanisms underlying them stand to have far-reaching implications for the diagnosis and treatment of diabetes and related metabolic states.
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