期刊
ARCHIVES OF VIROLOGY
卷 166, 期 5, 页码 1439-1446出版社
SPRINGER WIEN
DOI: 10.1007/s00705-021-05026-w
关键词
-
类别
资金
- CONACYT (Mexico) from RMDA [CB-220824, A1-S-9005]
- ALGE [CB-250696]
- Fundacion Miguel Aleman
- CONACYT
The NS3 protein of dengue virus is initially present in the nucleus of Huh7 cells during early infection, but later mainly localizes in the cytoplasm.
Although dengue virus (DENV) replication occurs in the cytoplasm, the nucleus plays an essential role during infection. Both the capsid protein (C) and non-structural protein 5 (NS5) are translocated into the infected cell nucleus to favor viral replication. Previously, our group reported the nuclear localization of the NS3 protein during DENV infection of mosquito cells; however, the nuclear localization of the DENV NS3 protein in human host cells has not been described. Here, we demonstrated that NS3 is present in the nucleus of Huh7 cells at early infection times, and later, it is mainly located in the cytoplasm.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据