4.6 Article

Association of Leptin Levels and Disease Activity in Patients with Early Rheumatoid Arthritis

期刊

ARCHIVES OF MEDICAL RESEARCH
卷 52, 期 5, 页码 544-553

出版社

ELSEVIER SCIENCE INC
DOI: 10.1016/j.arcmed.2021.02.002

关键词

Rheumatoid arthritis; insulin resistance; leptin; resistin; RBP4

向作者/读者索取更多资源

This study investigated the relationship between disease activity and adipocytokine levels in early rheumatoid arthritis patients, finding that those with high disease activity had higher BMI and leptin levels, which decreased after treatment.
Objective. Previous studies have reported a link between metabolic parameters and disease activity in rheumatoid arthritis (RA), although the evidence is limited in early RA. We aimed to investigate the relationship between disease activity and adipocytokine levels in subjects with early RA. Methods. Forty-seven patients with early RA (symptom duration <12 months) were enrolled. Disease activity was determined by DAS28-CRP. Patients were treated with DMARDs according to the EULAR recommendations. Subjects were tested before and five months after treatment. Results. Early RA patients with high disease activity (DAS28-CRP > 4.9) had greater BMI (31.2 +/- 6.8 kg/m(2) vs. 26.7 +/- 4.1 kg/m(2); p = 0.006) and higher leptin levels (14.62 +/- 15.60 ng/mL vs. 7.82 +/- 8.00 ng/mL; p = 0.048). Levels of other adipocytokines were not significantly different. Leptin levels were similar in subjects with mild/moderate disease activity and controls. DAS28-CRP was correlated with leptin (r = 0.303, p = 0.039). Leptin levels decreased significantly after treatment (from 10.86 +/- 12.34 ng/mL to 9.22 +/- 9.29 ng/mL; p = 0.047) along with insulin levels (from 13.68 +/- 21.90 mU/L to 7.09 +/- 4.72 mU/L; p = 0.010) and HOMA-IR (from 4.39 +/- 9.53 to 1.70 +/- 1.38; p = 0.012). HDL cholesterol levels increased (from 41 +/- 10 mg/dL48 +/- 10 mg/dL; p <0.001). Conclusion. Leptin levels were associated with disease activity in patients with early RA and these levels decreased after treatment with DMARDs. Further research is needed to elicit leptin's role to regulate disease activity in early RA. (C) 2021 Instituto Mexicano del Seguro Social (IMSS). Published by Elsevier Inc. All rights reserved.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.6
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据