期刊
AQUACULTURE
卷 533, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.aquaculture.2020.736110
关键词
Aflatoxin; Moringa oleifera; Oreochromis niloticus; Growth performance; Gene expression; Pathology
资金
- Biotechnology Lab., Faculty of Aquatic and Fisheries Sciences, Kafrelsheikh University, Egypt
This study evaluated the negative impacts of aflatoxin on Nile tilapia and the ameliorative effects of Moringa oleifera. The results showed that M. oleifera supplementation at 0.5% improved the adverse effects of aflatoxin on the growth performance and immune-related gene expression in the fish.
The present investigation evaluated the negative impacts of an aflatoxin-contaminated diet on the growth performance, serum and tissue biochemistry, gene expression of some immune-related genes in the liver, and pathological lesions in some organs of Nile tilapia. Moreover, the ameliorative effects of Moringa oleifera against fish aflatoxicosis were evaluated. Fish were allocated into four groups with the M. oleifera inclusion and/or aflatoxin contamination. The groups are the first group (negative control group) fed on a basal diet without any additives, the second group (positive control group) fed on a diet containing 1 mg aflatoxin B-1/kg diet. The third and fourth groups fed the contaminated diets supplemented with 0.5% and 1% M. oleifera seeds extract, respectively. Results showed the adverse effects of aflatoxin on the growth performance, serum biochemistry, liver tissue biochemistry, and gene expression and pathology of different organs of Nile tilapia. These adverse effects were ameliorated by the M. oleifera supplementation at 0.5%. In conclusion, the improvement of the biochemical and innate immune response parameters of tilapia fed diets contaminated with aflatoxin revealed the immunomodulatory role of the M. oleifera in the tilapia diet.
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