期刊
APPLIED SURFACE SCIENCE
卷 552, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.apsusc.2021.149428
关键词
Hydrothermal synthesis; Ag self-precipitation; Solar triggered; Photothermal therapy
类别
资金
- Ministry of Science and Technology, Taiwan [1082119M002005, 1092221E182059, 1093116F002002CC2]
- Chang Gung University [QZRPD181]
- Chang Gung Memorial Hospital, Linkou [CMRPD2H0173, BMRPC74]
The use of Ag NPs-precipitated TiO2 photocatalysts showed significant effectiveness and potential in both in vitro and in vivo photothermal therapy, with inhibitory effects on tumor growth. It has the potential to become an important treatment modality in photothermal therapy.
Photothermal therapy is considered to be a promising approach for minimally invasive tumor treatment. Before the clinical trial, the photo-induced heat production efficiency in tumor tissue needs improvement. Herein, we demonstrated a one-pot hydrothermal synthesis followed by calcination to prepare the Ag NPs-precipitated TiO2 photocatalysts. With calcination temperature ascending, anatase TiO2 transformed into rutile TiO2, and selfprecipitated Ag NPs vanished. Besides, fibers started to sinter with adjacent fibers, transforming into the bulk form. Due to the rich Ag NPs precipitated on the surface, leading to strong surface plasma resonance, Ag doped anatase TiO2 NFs (STF) presented the superior photocatalytic activity. Under the irradiation, 10,000 ppm of STF showed significant temperature enhancement in the photothermal conversion in vitro and the photothermal therapy in vivo. The body surface temperature can be increased up to 47.96 ?C with an irradiation time of 5.0 min. Moreover, the tumor growth was inhibited for up to 24 days, and the survival rate of mice was extended. From the protein identification of HE and Caspase 3 stain, STF proficiently disturbed the tumor expansion and led to tumor cell apoptosis. STF triggered by xenon lamp irradiation contributed to the significant tumor ablation and showed great potential in photothermal therapy.
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