期刊
APPLIED CLAY SCIENCE
卷 203, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.clay.2021.106000
关键词
Cationic drug loading; Layered double hydroxide; Systematic intercalation; Anticancer activity
资金
- Radiation Technology R&D program through the National Research Foundation of Korea- Ministry of Science and ICT & Future Planning [2017M2A2A6A05016600, 2017M2A2A6A05093711, 2020R1F1A1073107]
- Basic Science Research Program through the National Research Foundation of Korea - Ministry of Science and ICT & Future Planning [2017M2A2A6A05016600, 2017M2A2A6A05093711, 2020R1F1A1073107]
- National Research Foundation of Korea [2020R1F1A1073107] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
The study demonstrated the intercalation of a cationic anticancer drug, doxorubicin (DOX), and an anionic polymer, polyacrylic acid (PAA), into layered double hydroxide (LDH) to enhance drug carrier properties. The DOX-PAA-LDH hybrid exhibited favorable size for cellular uptake, continuously provided drugs to endosomal cells during endocytosis and exocytosis, and showed improved anticancer activity against human osteosarcoma cells and human lung adenocarcinoma epithelial cells.
A cationic anticancer drug, doxorubicin (DOX), was intercalated into layered double hydroxide (LDH) with an anionic polymer (polyacrylic acid (PAA)) to introduce the advantages of LDH as a drug carrier to DOX. Through X-ray diffraction patterns, Fourier-transform-infrared spectra, zeta-potential and X-ray photoelectron spectra showed that, PAA and DOX were intercalated in LDH interlayers through electrostatic stabilization between the carboxylate of PAA and LDH layer and between the carboxylate PAA backbone and DOX. Scanning electron microscopic images and dynamic light scattering results revealed that the DOX-PAA-LDH hybrid showed a favorable size for cellular uptake and enhanced permeability and retention, with a - 300 nm hydrodynamic radius and - 160 nm primary particle size. According to the bio-transmission electron microscopic images and confocal microscopic images, the DOX-PAA-LDH hybrid continuously provides drugs to endosomal cells during endocytosis and exocytosis. In accordance with these results, DOX-PAA-LDH showed improved anticancer activity against human osteosarcoma cells (MG-63) and human lung adenocarcinoma epithelial cells (A549) due to the advantages of LDH as a drug carrier.
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