4.6 Review Book Chapter

Integrated Patterning Programs During Drosophila Development Generate the Diversity of Neurons and Control Their Mature Properties

期刊

ANNUAL REVIEW OF NEUROSCIENCE, VOL 44, 2021
卷 44, 期 -, 页码 153-172

出版社

ANNUAL REVIEWS
DOI: 10.1146/annurev-neuro-102120-014813

关键词

Drosophila; neurogenesis; spatial patterning; temporal patterning; Notch; sensory organ precursor

资金

  1. National Institutes of Health (NIH) [R01 EY017916, R21 NS095288]
  2. NYSTEM [DOH01-C32604GG]
  3. NYU
  4. Swedish Research Council (Vetenskapsradet VR grant) [2016-06726]
  5. NIH [T32 HD007520]
  6. Swedish Research Council [2016-06726] Funding Source: Swedish Research Council

向作者/读者索取更多资源

During Drosophila neurogenesis, neural stem cells produce a variety of neurons through spatial and temporal patterning mechanisms. Simple patterning systems like Notch can be reiteratively used to generate different neuronal types, while different modes of temporal patterning may be linked. Integration of specification programs leads to the terminal features of different neuronal types.
During the approximately 5 days of Drosophila neurogenesis (late embryogenesis to the beginning of pupation), a limited number of neural stem cells produce approximately 200,000 neurons comprising hundreds of cell types. To build a functional nervous system, neuronal types need to be produced in the proper places, appropriate numbers, and correct times. We discuss how neural stem cells (neuroblasts) obtain so-called area codes for their positions in the nervous system (spatial patterning) and how they keep time to sequentially produce neurons with unique fates (temporal patterning). We focus on specific examples that demonstrate how a relatively simple patterning system (Notch) can be used reiteratively to generate different neuronal types. We also speculate on how different modes of temporal patterning that operate over short versus long time periods might be linked. We end by discussing how specification programs are integrated and lead to the terminal features of different neuronal types.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.6
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据