Integrated Patterning Programs During Drosophila Development Generate the Diversity of Neurons and Control Their Mature Properties

During the approximately 5 days of Drosophila neurogenesis (late embryogenesis to the beginning of pupation), a limited number of neural stem cells produce approximately 200,000 neurons comprising hundreds of cell types. To build a functional nervous system, neuronal types need to be produced in the proper places, appropriate numbers, and correct times. We discuss how neural stem cells (neuroblasts) obtain so-called area codes for their positions in the nervous system (spatial patterning) and how they keep time to sequentially produce neurons with unique fates (temporal patterning). We focus on specific examples that demonstrate how a relatively simple patterning system (Notch) can be used reiteratively to generate different neuronal types. We also speculate on how different modes of temporal patterning that operate over short versus long time periods might be linked. We end by discussing how specification programs are integrated and lead to the terminal features of different neuronal types.

Automated summary

During Drosophila neurogenesis, neural stem cells produce a variety of neurons through spatial and temporal patterning mechanisms. Simple patterning systems like Notch can be reiteratively used to generate different neuronal types, while different modes of temporal patterning may be linked. Integration of specification programs leads to the terminal features of different neuronal types.