期刊
ANNUAL REVIEW OF BIOCHEMISTRY, VOL 90, 2021
卷 90, 期 -, 页码 137-164出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-biochem-080320-110356
关键词
DNA repair; DNA double-strand break; nonhomologous end joining; DNA end synapsis; DNA end processing
资金
- National Institutes of Health [R01GM115487]
- Damon Runyon Postdoctoral Research Fellowship
DNA double-strand breaks are mainly repaired through nonhomologous end joining (NHEJ) in vertebrates, which requires efficient end synapsis and processing mechanisms to maintain genome stability.
DNA double-strand breaks pose a serious threat to genome stability. In vertebrates, these breaks are predominantly repaired by nonhomologous end joining (NHEJ), which pairs DNA ends in a multiprotein synaptic complex to promote their direct ligation. NHEJ is a highly versatile pathway that uses an array of processing enzymes to modify damaged DNA ends and enable their ligation. The mechanisms of end synapsis and end processing have important implications for genome stability. Rapid and stable synapsis is necessary to limit chromosome translocations that result from the mispairing of DNA ends. Furthermore, end processing must be tightly regulated to minimize mutations at the break site. Here, we review our current mechanistic understanding of vertebrate NHEJ, with a particular focus on end synapsis and processing.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据