期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 60, 期 20, 页码 11464-11473出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202102180
关键词
drug delivery; photodynamic therapy; size transformation; tumor microenvironments
资金
- National Natural Science Foundation of China [21974062, 92053102, 21834004]
- program B for Outstanding PhD candidate of Nanjing University
T-PFRT nanoframework can adapt to and remodel the abnormal tumor microenvironment, effectively inhibiting tumor growth and metastasis. By overcoming stroma and hypoxia barriers, it achieves excellent therapeutic outcomes.
Abnormal tumor microenvironment (TME) facilitates tumor proliferation and metastasis and establishes physiological barriers for effective transport of therapeutics inside the tumor, posing great challenges for cancer treatment. We designed a core-satellite size transformable nanoframework (denoted as T-PFRT) that can synchronously adapt to and remold TME for augmenting photodynamic therapy to inhibit tumor growth and prevent tumor metastasis. Upon matrix metalloproteinase 2 (MMP2)-responsive dissociation of the nanoframework in TME, the core structure loaded with TGF beta signaling pathway inhibitor and oxygen-carrying hemoglobin aims to stroma remodeling and hypoxia relief, allowing photosensitizer-encapsulated satellite particles to penetrate to deep-seated tumor for oxygen-fueled photodynamic therapy. T-PFRT could overcome the stroma and hypoxia barriers for delivering therapeutics and gain excellent therapeutic outcomes in the treatment of primary and metastatic tumors.
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