期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 60, 期 17, 页码 9553-9561出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202017349
关键词
cyanine; fluorescence imaging; hypoxia-dependent photolysis; near-infrared photocages; photoacoustic imaging
资金
- NSFC/China [21788102, 21878087, 21908060]
- Shanghai Municipal Science and Technology Major Project [2018SHZDZX03]
- Innovation Program of Shanghai Municipal Education Commission, the Shuguang Program [18SG27]
- China Postdoctoral Science Foundation [2019M651417]
Researchers have developed a hypoxia-dependent photoactivation mechanism for precise manipulation of biological events and in vivo feedback regulation. This novel approach overcomes the limitation of oxygen-dependence in current near-infrared photocages, expanding the toolbox for targeted therapy.
Photocaging holds promise for the precise manipulation of biological events in space and time. However, current near-infrared (NIR) photocages are oxygen-dependent for their photolysis and lack of timely feedback regulation, which has proven to be the major bottleneck for targeted therapy. Herein, we present a hypoxia-dependent photo-activation mechanism of dialkylamine-substituted cyanine (Cy-NH) accompanied by emissive fragments generation, which was validated with retrosynthesis and spectral analysis. For the first time, we have realized the orthogonal manipulation of this hypoxia-dependent photocaging and dual-modal optical signals in living cells and tumor-bearing mice, making a breakthrough in the direct spatiotemporal control and in vivo feedback regulation. This unique photoactivation mechanism overcomes the limitation of hypoxia, which allows site-specific remote control for targeted therapy, and expands the photo-trigger toolbox for on-demand drug release, especially in a physiological context with dual-mode optical imaging under hypoxia.
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