Fabricating Nanosheets and Ratiometric Detection of 5-Fluorouracil by Covalent Organic Framework Hybrid Material

Covalent organic framework (COF) nanosheets (NSs) are a new member in the family of two-dimensional (2D) nanomaterials that received increasing attention. The ability to prepare COF NSs with rapid acquisition is of great importance to explore their distinctive properties and potential applications. Herein, we elaborate design a new COF hybrid material EB-TFP:Eu(BTA)(4) as a sensing platform. In the process of ratiometric fluorescence detection of 5-fluorouracil (5FU), an anticancer drug, we realize the preparation of COF NSs. Interaction occurs between 5FU and COF hybrid material, where the interlayer pi-pi stacking of COF was weakened, benefiting the exfoliation of bulk COF to acquire 2D COF NSs. This strategy provides not only a sensitive and selective 5FU sensor but also a significant inspiration for engineering 2D COF NSs.

Automated summary

COF nanosheets, a new member in 2D nanomaterials, show potential in drug detection with high sensitivity and selectivity. Interaction with drugs promotes the preparation of COF nanosheets and their application in drug detection.