期刊
ANALYTICAL CHEMISTRY
卷 93, 期 7, 页码 3378-3385出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.analchem.0c04260
关键词
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资金
- National Natural Science Foundation of China [21676113, 21772054]
- Distinguished Young Scholar of Hubei Province [2018CFA079]
- 111 Project [B17019]
- Scholar support program of CCNU [0900-31101090002]
- Research Fund Program of the Guangdong Key Laboratory of Radioactive and Rare Resource Utilization [2018B030322009]
- Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules, Hubei University, Wuhan, P. R. China [KLSAOFM2012]
- Excellent Doctoral Dissertation Cultivation Grant of CCNU from the colleges' basic research and operation of MOE [2019YBZZ029]
In this study, a thienoisoindigo fluorophore was utilized to construct near-infrared fluorescent materials with aggregation-induced emission, showing excellent photostability and lysosomal targeting capability for in vivo fluorescence imaging.
Thienoisoindigo as a popular conjugated skeleton has been constantly applied in the construction of organic optoelectronic materials. Exploring its new applications in fluorescent sensors and bioimaging is helpful to extend its potential. In this work, a thienoisoindigo fluorophore was first selected as a building block to be applied in the construction of the near-infrared fluorescent materials with an aggregation-induced emission manner through introducing triarylamine, thiophene-bridged triarylamine, and N,N-dimethyl styrene, respectively. These fluorescent agents showed the near-infrared emission and possessed typical aggregation-induced emission behavior. Although they had low band gaps and near-infrared emission, they presented remarkable photostability. Especially, thiophene-bridged triarylamine and N,N-dimethyl styrene-coated thienoisoindigos exhibited strong lysosomal targeting capability, and they could also serve for fluorescence imaging in vivo.
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