Infections in Cirrhosis: A Guide for the Clinician

Cirrhosis contributes significantly to morbidity and mortality worldwide. Infections in patients with cirrhosis are common and significantly impact health-related quality of life. As our understanding of immune dysfunction associated with cirrhosis grows and as rates of drug-resistant organisms increase, the management of infections in cirrhosis has become increasingly nuanced. In this review, we discuss the current understanding of cirrhosis-associated immune deficiency, review the most common infections in patients with cirrhosis, and highlight techniques for the general clinician in the prevention and treatment of infections in this high-risk population. (C) 2021 Elsevier Inc. All rights reserved.

Automated summary

Cirrhosis is a significant contributor to morbidity and mortality worldwide, with infections impacting quality of life. Understanding immune dysfunction and managing infections in cirrhosis has become more nuanced with increasing rates of drug-resistant organisms. This review discusses cirrhosis-associated immune deficiency, common infections, and techniques for prevention and treatment in high-risk populations.