4.6 Review

2021 Update on Diffuse large B cell lymphoma: A review of current data and potential applications on risk stratification and management

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Hematology

Brentuximab vedotin in combination with rituximab, cyclophosphamide, doxorubicin, and prednisone as frontline treatment for patients with CD30-positive B-cell lymphomas

Jakub Svoboda et al.

Summary: In the trial of using BV-R-CHP combination therapy for CD30-positive B-cell lymphomas, toxicity was limited with no treatment-related deaths, high overall response rate and complete response rate, high utilization of consolidative radiation, and ideal 2-year survival rates.

HAEMATOLOGICA (2021)

Article Hematology

A phase 2 study of venetoclax plus R-CHOP as first-line treatment for patients with diffuse large B-cell lymphoma

Franck Morschhauser et al.

Summary: The study evaluated the efficacy and safety of venetoclax with R-CHOP in treating DLBCL, showing that adding venetoclax can increase overall response rate and PFS, particularly in the subgroup of patients with Bcl-2 protein overexpression.
Article Hematology

Final results of a phase 1 study of loncastuximab tesirine in relapsed/refractory B-cell non-Hodgkin lymphoma

Mehdi Hamadani et al.

Summary: Loncastuximab tesirine, an antibody-drug conjugate, shows promising efficacy and safety in patients with relapsed or refractory B-cell non-Hodgkin lymphoma, especially for certain specific lymphoma subtypes. This study suggests that loncastuximab tesirine could be a valuable treatment option for these patients and warrants further investigation in phase 2 trials.
Review Oncology

Unlocking the potential of antibody-drug conjugates for cancer therapy

Joshua Z. Drago et al.

Summary: Nine ADCs are currently approved for cancer treatment, with many more in development. Advances in synthetic biochemistry have led to a new generation of ADCs promising improved tissue specificity and cytotoxicity. Despite impressive activity against treatment-refractory cancers, challenges such as systemic toxicity and acquired resistance remain. This review discusses the design, mechanism of action, and limitations of ADCs, proposing strategies to maximize their therapeutic benefit for cancer patients.

NATURE REVIEWS CLINICAL ONCOLOGY (2021)

Article Hematology

A randomized phase 2/3 study of R-CHOP vs CHOP combined with dose-dense rituximab for DLBCL: the JCOG0601 trial

Ken Ohmachi et al.

Summary: Rituximab plus cyclophosphamide-doxorubicin-vincristine-prednisone (R-CHOP) is the standard treatment for untreated diffuse large B-cell lymphoma (DLBCL), but the addition of dose-dense weekly rituximab to CHOP did not improve progression-free survival (PFS) in patients with DLBCL.

BLOOD ADVANCES (2021)

Article Oncology

Polatuzumab Vedotin in Relapsed or Refractory Diffuse Large B-Cell Lymphoma

Laurie H. Sehn et al.

JOURNAL OF CLINICAL ONCOLOGY (2020)

Article Oncology

Cancer statistics, 2020

Rebecca L. Siegel et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2020)

Article Hematology

Checkpoint blockade treatment sensitises relapsed/refractory non-Hodgkin lymphoma to subsequent therapy

Nicole A. Carreau et al.

BRITISH JOURNAL OF HAEMATOLOGY (2020)

Article Medicine, General & Internal

Tisagenlecleucel in Adult Relapsed or Refractory Diffuse Large B-Cell Lymphoma

Stephen J. Schuster et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Article Medicine, General & Internal

Genetics and Pathogenesis of Diffuse Large B-Cell Lymphoma

R. Schmitz et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Review Medicine, General & Internal

Chimeric Antigen Receptor Therapy

Carl H. June et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Article Medicine, General & Internal

Axicabtagene Ciloleucel CAR T-Cell Therapy in Refractory Large B-Cell Lymphoma

S. S. Neelapu et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

Article Oncology

Salvage Regimens With Autologous Transplantation for Relapsed Large B-Cell Lymphoma in the Rituximab Era

Christian Gisselbrecht et al.

JOURNAL OF CLINICAL ONCOLOGY (2010)