期刊
AMERICAN JOURNAL OF DERMATOPATHOLOGY
卷 43, 期 7, 页码 521-524出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/DAD.0000000000001874
关键词
T-cell prolymphocytic leukemia; dermatomyositis; cutaneous lesion; periorbital ecchymosis; alemtuzumab
类别
T-cell prolymphocytic leukemia (TPLL) is a rare form of leukemia characterized by T lymphocytes at an intermediate stage of development with varied facial involvement. Diagnosis of TPLL involves flow cytometry and histopathology, and dermatologists should be aware of its unique features.
T-cell prolymphocytic leukemia (TPLL) is a rare form of leukemia by T lymphocytes at a post-thymic intermediate stage of development with an alpha/beta immunophenotype. Facial involvement is common in TPLL and displays significant heterogeneity of the lesions' description and location. TPLL also contains a wide array of histology findings, cell cytology, and molecular studies. Here, we describe a TPLL patient who presented with an ill-defined erythematous patch involving the right axilla progressing to the left axilla, upper back, and face that resembled dermatomyositis. The diagnosis of TPLL was established using flow cytometry of bone marrow and peripheral blood, and histopathology of the involved skin. Dermatologists should be aware of these unique features.
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