Thoracic Aortic Calcium for the Prediction of Stroke Mortality (from the Coronary Artery Calcium Consortium)

Thoracic aortic calcium(TAC) is an important marker of extracoronary atherosclerosis with established predictive value for all-cause mortality. We sought to explore the predic-tive value of TAC for stroke mortality, independent of the more established coronary artery calcium (CAC) score. The CAC Consortium is a retrospectively assembled data-base of 66,636 patients aged >= 18 years with no previous history of cardiovascular disease, baseline CAC scans for risk stratification, and follow-up for 12 +/- 4 years. CAC scans cap-ture the adjacent thoracic aorta, enabling assessment of TAC from the same images. TAC was available in 41,066 (62%), and was primarily analyzed as present or not present. To account for competing risks for nonstroke death, we utilized multivariable-adjusted Fine and Gray competing risk regression models adjusted for traditional cardiovascular risk factors and CAC score. The mean age of participants was 53.8 +/- 10.3 years, with 34.4% female. There were 110 stroke deaths during follow-up. The unadjusted subdistribution hazard ratio (SHR) for stroke mortality in those who had TAC present compared with those who did not was 8.80 (95% confidence interval [CI]: 5.97, 12.98). After adjusting for traditional risk factors and CAC score, the SHR was 2.21 (95% CI:1.39,3.49). In sex-strat-ified analyses, the fully adjusted SHR for females was 3.42 (95% CI: 1.74, 6.73) while for males it was 1.55 (95% CI: 0.83, 2.90). TAC was associated with stroke mortality indepen-dent of CAC and traditional risk factors, more so in women. The presence of TAC appears to be an independent risk marker for stroke mortality. (C) 2021 Elsevier Inc. All rights reserved.

Automated summary

Thoracic aortic calcium (TAC) is independently associated with stroke mortality, regardless of coronary artery calcium (CAC) and traditional risk factors, especially in women. The presence of TAC appears to be an independent risk marker for stroke mortality.