期刊
ALZHEIMERS & DEMENTIA
卷 17, 期 8, 页码 1329-1341出版社
WILEY
DOI: 10.1002/alz.12299
关键词
cognitive reserve; diagnosis; frontotemporal dementia; magnetic resonance imaging; neuroimaging; progression; resilience; survival
资金
- Health Department of the Government of Catalonia (grant PERIS) [SLT002/16/00408]
- NIH [AG019724, AG032306, AG045390, NS092089, AG045333, AG056749, AG062422, AG061253, AG058752, K24AG053435]
- Larry. L. Hillblom Foundation [2018-A-025-FEL, 2017-A-004-FEL, 2014-A-004-NET]
- Association for Frontotemporal Degeneration
- Fondo de Investigaciones Sanitario (FIS)
- Instituto de Salud Carlos III [PI14/01126, PI17/01019, PI13/01532, PI16/01825, PI18/00335, INT19/00016, PI18/00435, PI15/01618, PI14/1561, PI18/00326, AC14/00013, PI17/01896]
- CIBERNED program (Program 1, Alzheimer Disease to AL and SIGNAL study, www.signalstudy.es)
- Marato TV3 grant [20141210, 044412, 20143810]
- Generalitat de Catalunya [2014SGR-0235]
- Generalitat de Catalunya (PERIS) [SLT006/17/125, SLT006/17/00119]
- BBVA foundation
- Fundacio Bancaria La Caixa
- Global Brain Health Institute
- Rio Hortega grant from Instituto de Salud Carlos III [CM17/00074]
- Emili Letang post-residency research grant from Hospital Clinic de Barcelona
- Sysley D'Ornano Foundation
- Jerome Lejeune Foundation
- [R01AG059794]
The study revealed that women with bvFTD exhibited greater atrophy burden in the frontotemporal regions compared to men, despite having similar clinical characteristics. Additionally, women showed better executive function performance and experienced fewer changes in apathy, sleep, and appetite compared to men at a similar level of atrophy.
Introduction: Biological sex is an increasingly recognized factor driving clinical and structural heterogeneity in Alzheimer's disease, but its role in the behavioral variant of frontotemporal dementia (bvFTD) is unknown. Methods: We included 216 patients with bvFTD and 235 controls with magnetic resonance imaging (MRI) from a large multicenter cohort. We compared the clinical characteristics and cortical thickness between men and women with bvFTD and controls. We followed the residuals approach to study behavioral and cognitive reserve. Results: At diagnosis, women with bvFTD showed greater atrophy burden in the frontotemporal regions compared to men despite similar clinical characteristics. For a similar amount of atrophy, women demonstrated better-than-expected scores on executive function and fewer changes in apathy, sleep, and appetite than men. Discussion: Our findings suggest that women might have greater behavioral and executive reserve than men, and neurodegeneration must be more severe in women to produce symptoms similar in severity to those in men.
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