4.2 Article

Phosphatidylethanol as Blood Biomarker of Alcohol Consumption in Early Pregnancy: An Observational Study in 4,067 Pregnant Women

期刊

ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH
卷 45, 期 4, 页码 886-892

出版社

WILEY
DOI: 10.1111/acer.14577

关键词

Pregnancy; PEth; Alcohol Biomarkers; Fetal Alcohol Syndrome; Fetal Alcohol Spectrum Disorders

资金

  1. Norwegian Women's Public Health Association
  2. Department of Clinical Pharmacology and Clinic of Substance Use and Addiction Medicine, St. Olav University Hospital, Trondheim, Norway

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This study investigated the prevalence of early prenatal alcohol exposure in a general population of pregnant women in Norway, using positive PEth values as an indicator. The results showed that approximately 1.4% of women had a positive PEth sample around gestational week 12, while 0.4% had a positive sample around week 24. Further research on using PEth as a diagnostic tool for alcohol exposure in the antenatal setting is warranted.
Background The teratogenic effects of alcohol are well documented, but there is a lack of screening methods to detect alcohol use during pregnancy. Phosphatidylethanol 16:0/18:1 (PEth) is a specific and sensitive biomarker reflecting alcohol intake up to several weeks after consumption. The aim of this study was to investigate the prevalence of positive PEth values as an indicator of early prenatal alcohol exposure in a general population of pregnant women. Methods Rhesus typing is routinely performed in Norway in all pregnancies around gestational week 12. Rhesus-negative women have an additional test taken around week 24. Blood samples submitted to St. Olav University Hospital in Trondelag, Norway, for Rhesus typing during the period September 2017 to October 2018 were collected. A total of 4,533 whole blood samples from 4,067 women were analyzed for PEth (limit of quantification of 0.003 mu M). Results Fifty-eight women had a positive PEth sample. Of these, 50 women were positive around gestational week 12, 3 women were positive around week 24, and in 5 cases, the timing was unknown. There were no significant differences in proportions of women with positive PEth values related to age, or rural versus urban residency. Conclusion In an unselected pregnant population in Norway, 1.4% had a positive PEth sample around gestational week 12, whereas 0.4% had a positive sample around week 24. The use of PEth as an alcohol biomarker should be further investigated as a diagnostic tool in the antenatal setting.

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