Palladium-Catalyzed Carbonylative Synthesis of 1,5-Dihydro-2H-pyrrol-2-ones from Propargyl Amines and Benzyl Chlorides

A palladium-catalyzed double carbonylation of propargyl amines and benzyl chlorides employing benzene-1,3,5-triyl triformate (TFBen) as the CO source has been developed. By using this protocol, various 1,5-dihydro-2H-pyrrol-2-ones were produced in good yields.

Automated summary

A new palladium-catalyzed reaction has been developed for the efficient synthesis of 1,5-dihydro-2H-pyrrol-2-ones using benzene-1,3,5-triyl triformate as the CO source.