期刊
ADVANCED MATERIALS
卷 33, 期 13, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.202008540
关键词
duplex imaging; gold nanorods; manganese dioxide; NIR‐ II; photothermal‐ chemodynamic therapy
类别
资金
- National Key R&D Program of China [2018YFA0704000]
- Guangdong Province Natural Science Foundation of Major Basic Research and Cultivation Project [2018B030308003]
- Basic Research Program of Shenzhen [JCYJ20180507182413022, JCYJ20170412111100742]
- Shenzhen Science and Technology Program [KQTD20190929172538530]
- Fok Ying-Tong Education Foundation for Young Teachers in the Higher Education Institutions of China [161032]
A plasmonic modulation strategy of gold nanorods through manganese dioxide coating has been developed for NIR-II photoacoustic/magnetic resonance imaging-guided photothermal chemodynamic therapy. The LSPR peak of gold nanorods can be tuned by adjusting the thickness of the MnO2 layer, and the MnO2 layer can degrade in the tumor microenvironment for MR imaging and chemodynamic therapy. This strategy can be applied to other metal nanomaterials for construction of a new class of NIR-II nanotheranostics.
Nanotheranostic agents of gold nanomaterials in the second near-infrared (NIR-II) window have attracted significant attention in cancer management, owing to the reduced background signal and deeper penetration depth in tissues. However, it is still challenging to modulate the localized surface plasmon resonance (LSPR) of gold nanomaterials from the first near-infrared (NIR-I) to NIR-II region. Herein, a plasmonic modulation strategy of gold nanorods (GNRs) through manganese dioxide coating is developed for NIR-II photoacoustic/magnetic resonance (MR) duplex-imaging-guided NIR-II photothermal chemodynamic therapy. GNRs are coated with silica dioxide (SiO2) and then covered with magnesium dioxide (MnO2) to obtain the final product of GNR@SiO2@MnO2 (denoted as GSM). The LSPR peak of GNRs could be tuned by adjusting the thickness of the MnO2 layer. Theoretical simulations reveal that this plasmonic modulation is mainly due to the change of refraction index around the GNRs after coating with the MnO2 layer. Additionally, the MnO2 layer is demonstrated to degrade into Mn2+ ions in response to peroxide and acidic protons in the tumor microenvironment, which allows for MR imaging and chemodynamic therapy. This plasmonic modulation strategy can be adapted to other metal nanomaterials and the construction of a new class of NIR-II nanotheranostics.
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