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Monotherapy and Combination Therapy Using Anti-Angiogenic Nanoagents to Fight Cancer

期刊

ADVANCED MATERIALS
卷 33, 期 15, 页码 -

出版社

WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.202005155

关键词

anti‐ angiogenic therapy; combination therapy; monotherapy; nanoparticles

资金

  1. NNSF of China [61525402, 61775095]
  2. Jiangsu Provincial key research and development plan [BE2017741]
  3. Jiangsu Province Policy Guidance Plan [BZ2019014]
  4. NIH [R33ES025606, R21AI135367]

向作者/读者索取更多资源

Anti-angiogenic therapy targeting vascular endothelial cells to prevent tumor growth has shown modest clinical efficiency in solid tumors. Combining advanced drug delivery techniques or other therapeutic strategies with anti-angiogenic therapy can result in significantly synergistic effects in fighting cancer. Clinical difficulties of traditional anti-angiogenic therapy are discussed, while promising applications of anti-angiogenic nanoagents in monotherapies and combination therapies are highlighted.
Anti-angiogenic therapy, targeting vascular endothelial cells (ECs) to prevent tumor growth, has been attracting increasing attention in recent years, beginning with bevacizumab (Avastin) through its Phase II/III clinical trials on solid tumors. However, these trials showed only modest clinical efficiency; moreover, anti-angiogenic therapy may induce acquired resistance to the drugs employed. Combining advanced drug delivery techniques (e.g., nanotechnology) or other therapeutic strategies (e.g., chemotherapy, radiotherapy, phototherapy, and immunotherapy) with anti-angiogenic therapy results in significantly synergistic effects and has opened a new horizon in fighting cancer. Herein, clinical difficulties in using traditional anti-angiogenic therapy are discussed. Then, several promising applications of anti-angiogenic nanoagents in monotherapies and combination therapies are highlighted. Finally, the challenges and perspectives of anti-angiogenic cancer therapy are summarized. A useful introduction to anti-angiogenic strategies, which may significantly improve therapeutic outcomes, is thus provided.

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