期刊
ADVANCED FUNCTIONAL MATERIALS
卷 31, 期 19, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.202011230
关键词
hydrogels; injectable; on‐ demand dissolutions; self‐ healing; wound dressing
类别
资金
- National Natural Science Foundation of China [51773196, 51973220, 51703225, 51833010]
- Jilin Provincial science and technology development program [20190103022JH]
- Youth Innovation Promotion Association of Chinese Academy of Sciences [2017266]
An injectable self-healing hydrogel with rapid gelation and cysteine-specific on-demand dissolution was designed for wound dressings, showing excellent injectability, self-healing ability, and rapid cysteine-triggered dissolution. The hydrogel displayed favorable biocompatibility, achieved rapid wound closure in seconds, and fast on-demand dissolution for dressing changes, highlighting its potential for wound healing applications.
Rapid gelation and on-demand dissolution are key characteristics governing the effectiveness of clinic hydrogel wound dressings. Here, an injectable self-healing hydrogel with rapid gelation and cysteine-specific on-demand dissolution is designed to be used as wound dressings. The hydrogel is prepared based on the formation of tandem dynamic covalent bonds comprised of C(sic)C double bonds produced through the catalysis-free Knoevenagel condensation reaction and boronate ester linkages. The prepared hydrogel displays excellent injectability and self-healing ability, showing rapid cysteine-triggered on-demand dissolution owing to the formation of the thiazolidino boronate complex. When used as dressings for healing full-thickness wounds, the hydrogel shows favorable biocompatibility, achieves rapid wound closure in seconds, and fast on-demand dissolution for dressing changes. These data highlight the utility of the designed tandem dynamic covalent bonds-based hydrogel dressings for promising wound healing applications.
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