期刊
ADVANCED FUNCTIONAL MATERIALS
卷 31, 期 19, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.202010461
关键词
bioelectronic; conductive silk microfibre; diabetic wound; mussel inspired
类别
资金
- National Key Research and Development Program of China [2016YFB0700800]
- Key-Area Research and Development Program of Guang Dong Province [2019B010941002]
- NSFC [82072071, 82072073, 81771114, 81970967]
- Fundamental Research Funds for the Central Universities [2682020ZT79]
- Sichuan Science and Technology Program [2020YFS0173]
- Young Scientific and Technological Innovation Research Team Funds of Sichuan Province [20CXTD0106]
- Chengdu Science and Technology Program [2019-YF05-00349-SN]
Conductive silk microfibers were fabricated using a bioinspired method in this study, which were then used to make a conductive flexible silk fibroin patch for monitoring physiological signals and promoting chronic diabetic wound healing with excellent performance.
Ideal epidermal bioelectronics can be used not only for long-term detection of physiological signals for disease diagnosis but also for chronic disease treatment. Silk, an animal-derived fiber with good biocompatibility and skin-affinity, is widely used in flexible bioelectronics. However, silk fibers are insulating. In this study, ultralong conductive silk microfibers (mSFs) are fabricated by extracting mSF from raw silk using a bioinspired extraction-protection process with the assistance of polydopamine, followed by deposition of poly(3,4-ethylenedioxythiophene) (PEDOT) on its surface. The conductive mSFs are produced and used to fabricate a conductive flexible silk fibroin patch, which is used as a conformable bioelectronic for monitoring physiological signals. In addition, as the conductive mSF possessed anti-oxidative activity, the patch exhibits excellent performance in chronic diabetic wound healing by reducing inflammation and regulating oxidative stress. Thus, this bioinspired strategy produces conductive silk fibers that can be used as biocompatible building blocks, opening new avenues for employing passive silk as an active component in the design of epidermal wound repair biomaterials and next-generation flexible epidermal bioelectronics.
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