期刊
ADVANCED FUNCTIONAL MATERIALS
卷 31, 期 18, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.202100462
关键词
3D printing; high‐ strength hydrogels; meniscus substitutes; self‐ strengthening; self‐ thickening inks
类别
资金
- National Key Research and Development Program [2018YFA0703100]
- National Nature Science Foundation of China [51733006]
By utilizing a concentration-dependent H-bonding-strengthened mechanism, a self-thickening and self-strengthening strategy is proposed to directly 3D print latently H-bonding-reinforced hydrogels by loading concentrated NAGA monomer into low-strength PNAGA hydrogels. This method generates high-strength and antiswelling hydrogels, overcoming the trade-off between strength and printability.
3D printing of high-strength and antiswelling hydrogel-based load-bearing soft tissue scaffolds with similar geometric shape to natural tissues remains a great challenge owing to insurmountable trade-off between strength and printability. Herein, capitalizing on the concentration-dependent H-bonding-strengthened mechanism of supramolecular poly(N-acryloyl glycinamide) (PNAGA) hydrogel, a self-thickening and self-strengthening strategy, that is, loading the concentrated NAGA monomer into the thermoreversible low-strength PNAGA hydrogel is proposed to directly 3D printing latently H-bonding-reinforced hydrogels. The low-strength PNAGA serves to thicken the concentrated NAGA monomer, affording an appropriate viscosity for thermal-assisted extrusion 3D printing of soft PNAGA hydrogels bearing NAGA monomer and initiator, which are further polymerized to eventually generate high-strength and antiswelling hydrogels, due to the reconstruction of strong H-bonding interactions from postcompensatory PNAGA. Diverse polymer hydrogels can be printed with self-thickened corresponding monomer inks. Further, the self-thickened high-strength PNAGA hydrogel is printed into a meniscus, which is implanted in rabbit's knee as a substitute with in vivo outcome showing an appealing ability to efficiently alleviate the cartilage surface wear. The self-thickening strategy is applicable to directly printing a variety of polymer-hydrogel-based tissue engineering scaffolds without sacrificing mechanical strength, thus circumventing problems of printing high-strength hydrogels and facilitating their application scope.
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