期刊
ADVANCED FUNCTIONAL MATERIALS
卷 31, 期 16, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.202010196
关键词
cyanobacterial; photodynamic therapy; photosensitization; photosynthesis; upconversion nanoparticles
类别
资金
- National Key Research and Development Program of China [2016YFA0203700]
- National Natural Science Foundation of China [21835007, 22005327, 82001944, 51722211, 51672303]
- Key Research Program of Frontier Sciences, Chinese Academy of Sciences [ZDBS-LY-SLH029]
- Program of Shanghai Academic Research Leader [18XD1404300]
- Shanghai Municipal Government ST Project [17JC1404701]
- China Post-doctoral Science Foundation [2019TQ0231, 2020M671243, BX20200345]
The near infrared-driven PDT platform based on photosynthetic cyanobacterial cells hybridized with photosensitizer rose bengal (RB)-loaded upconversion nanoparticles, named as UR-Cyan cells, offers enhanced and sustainable PDT efficacy against tumor cells/tissues by promoting both oxygen production and singlet oxygen generation. This design provides a practical approach to overcome the hypoxic burden of PDT operations with excellent biocompatibility and clinical promises.
The hypoxic hallmark of tumor has aroused substantial burdens on a variety of therapeutic modalities including photodynamic therapy (PDT). Recently, biological oxygen evolution enabled by photosynthetic cyanobacterial cells has emerged as one of the most advanced and promising tissue oxygenation strategies, which is particularly beneficial for in situ tumor-PDT. Herein, a near infrared-driven PDT platform based on the photosynthetic cyanobacterial cells hybridized with photosensitizer rose bengal (RB)-loaded upconversion nanoparticles, named as UR-Cyan cells, is reported. Upon the irradiation of 980 nm laser and its upconversions to shorter wavelengths, the formulated UR-Cyan cells are both photosynthetically active for oxygen production and photosensitive for the subsequent singlet oxygen generation by the photosensitizer, resulting in enhanced and sustainable PDT efficacy against tumor cells/tissues. The present design offers a practical approach to conquer the hypoxic burden of PDT operations against a wide range of pathological lesions with excellent biocompatibility and clinical promises.
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