Genetic diversity of Leishmania tropica: Unexpectedly complex distribution pattern

In this study, we characterized a collection of clinical samples obtained from Syrian and Turkish patients with cutaneous leishmaniasis using internal transcribed spacer 1 (ITS1) sequences. All obtained sequences belonged to Leishmania tropica. Combining them with those available from GenBank allowed us performing a broad-scale analysis of genetic diversity for this species. We demonstrated that L. tropica has a complex phylogeographic pattern with some haplotypes being widespread across endemic countries and others restricted to particular regions. We hypothesize that at least some of them may be associated with alternative vectors or animal reservoirs.

Automated summary

This study characterized clinical samples from Syrian and Turkish patients with cutaneous leishmaniasis using ITS1 sequences, and found that Leishmania tropica exhibits a complex phylogeographic pattern. Some haplotypes are widespread across endemic countries while others are restricted to specific regions.