期刊
ACS NANO
卷 15, 期 3, 页码 3709-3735出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.0c09231
关键词
upconversion nanoparticles; heterostructure; rare earth; deep tissue penetration; near-infrared light; bioimaging; biosensing; phototherapy
类别
资金
- National Natural Science Foundation of China [11905123, 81971740, 31671011]
- Shanghai Sailing Program [19YF1415200]
- Innovative Research Team of High-Level Local Universities in Shanghai, Ministry of Education of Singapore (MOE) [MOE 2016-T3-1-004, R-397-000274-112, R-397-000-348-114]
- National Medical Research Council [NMRC/OFIRG/0071/2018, R-397-000-317-213]
- National University of Singapore
Heterostructured UCNPs, composed of UCNPs and other functional counterparts, exhibit bifunctional or multifunctional properties, overcoming challenges associated with a single component. They have potential applications in bioimaging, biodetection, and phototherapy.
Upconversion nanoparticles (UCNPs) represent a class of optical nanomaterials that can convert low-energy excitation photons to high-energy fluorescence emissions. On the basis of UCNPs, heterostructured UCNPs, consisting of UCNPs and other functional counterparts (metals, semiconductors, polymers, etc.), present an intriguing system in which the physicochemical properties are largely influenced by the entire assembled particle and also by the morphology, dimension, and composition of each individual component. As multicomponent nanomaterials, heterostructured UCNPs can overcome challenges associated with a single component and exhibit bifunctional or multifunctional properties, which can further expand their applications in bioimaging, biodetection, and phototherapy. In this review, we provide a summary of recent achievements in the field of heterostructured UCNPs in the aspects of construction strategies, synthetic approaches, and types of heterostructured UCNPs. This review also summarizes the trends in biomedical applications of heterostructured UCNPs and discusses the challenges and potential solutions in this field.
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