2D-Molybdenum Disulfide-Derived Ion Source for Mass Spectrometry

Generation of current or potential at nanostructures using appropriate stimuli is one of the futuristic methods of energy generation. We developed an ambient soft ionization method for mass spectrometry using 2D-MoS2, termed streaming ionization, which eliminates the use of traditional energy sources needed for ion formation. The ionic dissociation-induced electrokinetic effect at the liquid-solid interface is the reason for energy generation. We report the highest figure of merit of current generation of 1.3 A/m(2) by flowing protic solvents at 22 mu L/min over a 1 x 1 mm(2) surface coated with 2D-MoS2, which is adequate to produce continuous ionization of an array of analytes, making mass spectrometry possible. Weakly bound ion clusters and uric acid in urine have been detected. Further, the methodology was used as a self-energized breath alcohol sensor capable of detecting 3% alcohol in the breath.

Automated summary

The study demonstrates a novel method of generating current using nanostructures, based on the ionic dissociation-induced electrokinetic effect at the liquid-solid interface. By flowing protic solvents over a 2D-MoS2-coated surface, the generation of continuous ionization for mass spectrometry is achieved, while also showing potential for a self-energized breath alcohol sensor.