期刊
ACS APPLIED MATERIALS & INTERFACES
卷 13, 期 9, 页码 10778-10795出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.1c01238
关键词
gold nanodendrites; photoacoustic imaging; photodynamic therapy; Raman imaging; second near-infrared photothermal therapy
资金
- National Science Foundation [1508511]
- National Institute of Arthritis and Musculoskeletal and Skin Diseases [1R01AR067859]
- Division Of Materials Research
- Direct For Mathematical & Physical Scien [1508511] Funding Source: National Science Foundation
The fabricated Gold nanodendrite (AuND)-based nanotheranostic agents with versatile capabilities enabled multimodal imaging and synergistic therapies of NIR-II photothermal therapy and NIR-I photodynamic therapy for cancer treatment. The enhanced hyperthermia and production of reactive oxygen species within the tumors via MCM coating and mitochondria targeting provide a synergistic efficacy for tumor eradication with limited side effects, showing great potentials for clinical utility in cancer therapy.
Gold nanodendrite (AuND)-based nanotheranostic agents with versatile capabilities were fabricated by optimizing the geometrical configurations (dendrite length and density) of AuND to achieve localized surface plasmon resonance (LSPR) in near-infrared biowindow II (NIR-II), and then subsequently functionalizing with a mitochondria-targeting compound (triphenylphosphonium, TPP), loading with an NIR-photosensitizer (indocyanine green, ICG) and coating with the macrophage cell membrane (MCM) to trap ICG within AuND and selectively interact with MDA-MB-231 cells. The novel AuND-TPP-ICG@MCM system enabled the integration of multimodal fluorescence/photoacoustic/surface-enhanced Raman imaging with synergistic therapies of NIR-II photothermal therapy and NIR-I photodynamic therapy for cancer treatment. Enhanced hyperthermia and elevated production of reactive oxygen species within the tumors via MCM coating and mitochondria targeting afforded a synergistic efficacy for tumor eradication with limited side effects. The demonstrated biocompatibility, multi-imaging capability, and high therapeutic efficiency under NIR laser irradiation indicate the potentials of this multifunctional nanotheranostic platform for clinical utility in cancer therapy.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据