期刊
ACS APPLIED MATERIALS & INTERFACES
卷 13, 期 8, 页码 9542-9560出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.0c19562
关键词
aptamers; DNA nanotechnology; nanomaterials; diagnostics; therapeutics
资金
- National Natural Science Foundation of China [21827811]
- Research and development plan of key areas in Hunan Province [2019SK2201]
- Innovation science and technology plan of Hunan Province [2017XK2103]
The combination of nanomaterials and aptamers holds great potential in bioapplications, especially in the fields of diagnostics and therapeutics, with important applications in cellular analysis, imaging, targeted drug delivery, and cancer diagnosis/therapy.
In the past decades, various nanomaterials with unique properties have been explored for bioapplications. Meanwhile, aptamers, generated from the systematic evolution of ligands by exponential enrichment technology, are becoming an indispensable element in the design of functional nanomaterials because of their small size, high stability, and convenient modification, especially endowing nanomaterials with recognition capability to specific targets. Therefore, the incorporation of aptamers into nanomaterials offers an unprecedented opportunity in the research fields of diagnostics and therapeutics. Here, we focus on recent advances in aptamer-embedded nanomaterials for bioapplications. First, we briefly introduce the properties of nanomaterials that can be functionalized with aptamers. Then, the applications of aptamer-embedded nanomaterials in cellular analysis, imaging, targeted drug delivery, gene editing, and cancer diagnosis/therapy are discussed. Finally, we provide some perspectives on the challenges and opportunities that have arisen from this promising area.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据