期刊
ACS APPLIED MATERIALS & INTERFACES
卷 13, 期 5, 页码 6099-6108出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.0c22489
关键词
drug delivery; glioblastoma; nanobubbles; ultrasound; persistent luminescence bioimaging
资金
- Ministry of Science and Technology [MOST 107-2113-M-002-008-MY3, MOST 109-2112-M-003-011]
- National Taiwan University [NTU-AS-108L104301, AS-NTU-108-01]
- Academia Sinica Joint Program [NTU-AS-108L104301, AS-NTU-108-01]
The blood-brain barrier is a crucial barrier that protects the brain from external substances. Utilizing nanotechnology and ultrasound induction, this barrier can be temporarily opened for potential brain disease treatment.
The blood-brain barrier (BBB) is a physical barrier that selectively prevents certain substances from entering the brain through the blood. The BBB protects the brain from germs and causes difficulty in intracranial treatment. The chemotherapy drug temozolomide (TMZ), embedded in nanobubbles (NBs) and combined with persistent luminescent nanoparticles (PLNs), has been used to treat glioblastoma (GBM) effectively through image tracking. Through ultrasound induction, NBs produce cavitation that temporarily opens the BBB. Additionally, the PLNs release near-infrared emission and afterglow, which can penetrate deep tissues and improve the signal-to-noise ratio of bioimages. In this work, the nanosystem crossed the BBB for drug delivery and image tracking over rim allowing the enhancement of the drug's therapeutic effect on GBM. We hope that this nanosystem can be applied to the treatment of different brain diseases by embedding different drugs in NBs.
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