期刊
ACS APPLIED MATERIALS & INTERFACES
卷 13, 期 7, 页码 9006-9014出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.0c22658
关键词
antifouling; antibacterial; hydrophilic; zwitterion; biocompatibility
资金
- National Natural Science Foundation of China [51673081]
- Natural Sciences and Engineering Council of Canada
- College of Chemistry
By combining zwitterionic MPC with borneol compound, an excellent antifouling and antibacterial surface with superb hydrophilicity was prepared via Schiff-base bond. The copolymer's coordination between MPC and borneol moieties showed effective prevention of protein adsorption and inhibition of bacterial adhesion, making it a potential application in biomedical materials.
The development and application of natural antibacterial materials have always been the focus of biomedical research. Borneol as a natural antibacterial compound has received extensive attention. However, the hydrophobicity caused by its unique structure limits its application range to a certain extent. In this study, we combine zwitterionic 2-methacryloyloxyethyl phosphorylcholine (MPC) with a complex bicyclic monoterpene structure borneol compound and prepare an excellent antifouling and antibacterial surface via the Schiff-base bond. The prepared coating has excellent hydrophilicity verified by the contact angle (CA), and its polymer layer is confirmed by X-ray photoelectron spectroscopy (XPS). The zwitterion MPC and borneol moieties in the copolymer play a coordinating role, relying on super hydration and the special stereochemical structure to prevent protein adsorption and inhibit bacterial adhesion, respectively, which are demonstrated by bovine serum albumin (BSA) adsorption and antibacterial activity test. Moreover, the water-soluble borneol derivative as the antibacterial surfaces we designed here was biocompatible toward MRC-5 (lung fibroblasts), as showed by in vitro cytotoxicity assays. Such results indicate the potential application of the as-prepared hydrophilic surfaces in the biomedical materials.
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