期刊
ACS APPLIED MATERIALS & INTERFACES
卷 13, 期 11, 页码 12857-12865出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.0c22555
关键词
NIR-II fluorescence imaging; nucleophilic substitution; on-site immobilization; nanotheranostics; imaging-guided surgery; photothermal therapy
资金
- Training Program of the Major Research Plan of the National Natural Science Foundation of China [91959123]
- Key Research and Development Program of Social Development of Jiangsu Province [BE2018655]
- National Natural Science Foundation of China [81830052, 22077092]
- Open Project Program of the State Key Laboratory of Radiation Medicine and Protection [GZK1201916, GZK1202017]
- Construction project of the Shanghai Key Laboratory of Molecular Imaging [18DZ2260400]
- Shanghai Municipal Education Commission (Class II Plateau Disciplinary Construction Program of Medical Technology of SUMHS)
- Priority Academic Program Development of Jiangsu Higher Education Institutions
The development of an intelligent NIR-II nanoprobe showed great potential for NIR-II imaging-guided surgery and photothermal therapy of breast carcinoma in living mice, while also demonstrating improved tumor accumulation and retention time through covalent on-site-immobilization within tumors. This probe may provide an attractive means for precise cancer diagnosis and treatment.
Accurate diagnosis and efficient treatment of tumors are highly significant in battling cancer. Near-infrared II (NIR-II) fluorescence imaging shows big promise for deep tumor visualization in living systems due to high temporal and spatial resolution and deep tissue penetration capability, whereas the development of efficient NIR-II probes for tumor theranostics still faces a huge challenge. Herein, we have designed and constructed intelligent mPEG(5000)-PCL3000-encapsulated NIR-II nanoprobe ZM1068-NPs that showed great chemical stability and excellent biocompatibility. With the merits of the strong fluorescence in the NIR-II region and prominent optical-thermal conversion efficiency, this probe was successfully used for NIR-II imaging-guided surgery and photothermal therapy of breast carcinoma in living mice. More notably, it was for the first time found that ZM1068 dyes could be covalently on-site-immobilized within tumors through the thiol-chlor nucleophilic substitution reaction, resulting in improved tumor accumulation and retention time. We thus envision that this probe may provide an attractive means for precise cancer diagnosis and treatment.
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