期刊
FOOD SCIENCE OF ANIMAL RESOURCES
卷 41, 期 2, 页码 343-352出版社
KOREAN SOC FOOD SCIENCE ANIMAL RESOURCES
DOI: 10.5851/kosfa.2020.e93
关键词
cholesterol gallstone; mucin; Lactobacillus acidophilus; Lactobacillus fermentum; lithogenic diet
资金
- Seoul Dairy Cooperative
The study evaluated the effects of Lactobacillus acidophilus ATCC 43121 and L. fermentum MF27 on biochemical indices, cholesterol metabolism, and mucin expression in LD-induced C57BL/6J mice, showing that they can prevent the formation of cholesterol gallstones by reducing cholesterol levels and suppressing mucin expression in the gallbladder.
The objective of this study was to evaluate the effects of Lactobacillus acidophilus ATCC 43121 and L. fermentum MF27 on biochemical indices in the serum, cholesterol metabolism in the liver and mucin expression in the gallbladder in lithogenic diet (LD)-induced C57BL/6J mice to determine the preventive effects of lactobacilli on gallstone formation. By the end of 4 wk of the experimental period, mice fed on a LD with high-fat and high-cholesterol exhibited higher levels of total and low-density lipoprotein cholesterol in the serum compared to mice fed on control diet or LD with L. acidophilus ATCC 43121 (LD+P1; p<0.05). Cholesterol-lowering effects observed in the LD+P1 and LD with L. fermentum MF27 (LD+P2) groups were associated with reduced expression of 3-hydroxy-3-methylglutaryl coenzyme A reductase in the liver compared to the LD group (p<0.05). Furthermore, expression of the gel-forming mucin, including MUC5AB and MUC5B, was suppressed in the LD+P1 and LD+P2 groups compared to the LD group (p<0.05). Therefore, steady intake of both L. acidophilus ATCC 43121 and L. fermentum MF27 may have the ability to prevent the formation of cholesterol gallstones in LD-induced C57BL/6J mice.
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