期刊
CHEMOSENSORS
卷 8, 期 4, 页码 -出版社
MDPI
DOI: 10.3390/chemosensors8040118
关键词
biomarker; surface-enhanced Raman scattering; disease; tumor; viruses; Alzheimer's disease; cardiac muscle tissue injury; cell
资金
- National Research Foundation of Korea (NRF) - Korea government [NRF-2018R1A2A3074587, NRF-2020K2A9A2A06036299]
An overview of noteworthy new methods of biomarker determination based on surface-enhanced Raman scattering (SERS) is presented. Biomarkers can be used to identify the occurrence and development of diseases, which furthers the understanding of biological processes in the body. Accurate detection of a disease-specific biomarker is helpful for the identification, early diagnosis and prevention of a disease and for monitoring during treatment. The search for and discovery of valuable biomarkers have become important research hotspots. Different diseases have different biomarkers, some of which are involved in metabolic processes. Therefore, the fingerprint characteristics and band intensities in SERS spectra have been used to identify metabolites and analyze markers. As a promising technique, SERS has been widely used for the quantitative and qualitative determination of different types of biomarkers for different diseases. SERS techniques provide new technologies for the diagnosis of disease-related markers and determining the basis for clinical treatment. Herein, several SERS-based methods with excellent sensitivity and selectivity for the determination of biomarkers for tumors, viruses, Alzheimer's disease, cardiac muscle tissue injury, and cell activity are highlighted.
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