期刊
ENEURO
卷 8, 期 1, 页码 -出版社
SOC NEUROSCIENCE
DOI: 10.1523/ENEURO.0310-20.2020
关键词
3D printing; capacitive; object recognition; open source; rodent
资金
- NIH Summer Internship Program
- NIEHS Scholar Connect Program
Object recognition tasks are commonly used assays for studying learning and memory in rodents, but inconsistencies in conducting these tasks across labs exist. By designing and using standardized 3D-printed objects and utilizing capacitive sensing technology to measure object investigation, these inconsistencies can be resolved.
Object recognition tasks are widely used assays for studying learning and memory in rodents. Object recognition typically involves familiarizing mice with a set of objects and then presenting a novel object or displacing an object to a novel location or context. Learning and memory are inferred by a relative increase in time investigating the novel/displaced object. These tasks are in wide-spread use, but there are many inconsistencies in the way they are conducted across labs. Two major contributors to this are the lack of consistency in the method of measuring object investigation and the lack of standardization of the objects that are used. Current video-based automated algorithms can often be unreliable whereas manual scoring of object investigation is time consuming, tedious, and more subjective. To resolve these issues, we sought to design and implement 3D-printed objects that can be standardized across labs and use capacitive sensing to measure object investigation. Using a 3D printer, conductive filament, and low-cost off-the-shelf components, we demonstrate that employing 3D-printed capacitive touch objects is a reliable and precise way to perform object recognition tasks. Ultimately, this approach will lead to increased standardization and consistency across labs, which will greatly improve basic and translational research into learning and memory mechanisms.
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