4.6 Review

Incretin Hormones and Type 2 Diabetes-Mechanistic Insights and Therapeutic Approaches

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

Pharmacokinetics of exogenous GIP(1-42) in C57Bl/6 mice; Extremely rapid degradation but marked variation between available assays

Geke Aline Boer et al.

Summary: The pharmacokinetics of exogenous GIP in mice were studied, showing that DPP-4 inhibition prolongs GIP half-life. Additionally, variations in total and intact GIP measurements were found between different assay methods and sample preparation techniques.

PEPTIDES (2021)

Review Biochemistry & Molecular Biology

The glucose-dependent insulinotropic polypeptide signaling axis in the central nervous system

A. E. Adriaenssens et al.

PEPTIDES (2020)

Article Biochemistry & Molecular Biology

GIP analogues and the treatment of obesity-diabetes

Clifford J. Bailey

PEPTIDES (2020)

Review Biochemistry & Molecular Biology

The role of GIP in α-cells and glucagon secretion

Kimberley El et al.

PEPTIDES (2020)

Review Biochemistry & Molecular Biology

Molecular interactions of full-length and truncated GIP peptides with the GIP receptor - A comprehensive review

Maria Buur Nordskov Gabe et al.

PEPTIDES (2020)

Review Endocrinology & Metabolism

Incretin therapy for diabetes mellitus type 2

Jens Juul Holst

CURRENT OPINION IN ENDOCRINOLOGY DIABETES AND OBESITY (2020)

Article Multidisciplinary Sciences

Full-length human GLP-1 receptor structure without orthosteric ligands

Fan Wu et al.

NATURE COMMUNICATIONS (2020)

Review Medicine, General & Internal

GLP-1 Receptor Agonists and Diabetic Kidney Disease: A Call of Attention to Nephrologists

Jose Luis Gorriz et al.

JOURNAL OF CLINICAL MEDICINE (2020)

Review Pharmacology & Pharmacy

GLP-1 Receptor Agonists in Diabetic Kidney Disease: From Clinical Outcomes to Mechanisms

Daiji Kawanami et al.

FRONTIERS IN PHARMACOLOGY (2020)

Review Pharmacology & Pharmacy

A review of GLP-1 receptor agonists in type 2 diabetes: A focus on the mechanism of action of once-weekly agents

Susan Cornell

JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS (2020)

Article Endocrinology & Metabolism

Separate and Combined Effects of GIP and GLP-1 Infusions on Bone Metabolism in Overweight Men Without Diabetes

Natasha Chidekel Bergmann et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2019)

Article Endocrinology & Metabolism

GIP and GLP-1: Stepsiblings Rather Than Monozygotic Twins Within the Incretin Family

Michael A. Nauck et al.

DIABETES (2019)

Article Endocrinology & Metabolism

Reductions in Insulin Resistance are Mediated Primarily via Weight Loss in Subjects With Type 2 Diabetes on Semaglutide

Vivian A. Fonseca et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2019)

Editorial Material Endocrinology & Metabolism

Understanding the mechanisms of reversal of type 2 diabetes

Roy Taylor et al.

LANCET DIABETES & ENDOCRINOLOGY (2019)

Review Endocrinology & Metabolism

Paracrine crosstalk between intestinal L- and D-cells controls secretion of glucagon-like peptide-1 in mice

Sara L. Jepsen et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2019)

Review Endocrinology & Metabolism

Glucagon-like peptide 1 (GLP-1)

T. D. Mueller et al.

MOLECULAR METABOLISM (2019)

Review Medicine, Research & Experimental

Molecular mechanisms by which GLP-1 RA and DPP-4i induce insulin sensitivity

Habib Yaribeygi et al.

LIFE SCIENCES (2019)

Review Endocrinology & Metabolism

Are all GLP-1 agonists equal in the treatment of type 2 diabetes?

Michael A. Nauck et al.

EUROPEAN JOURNAL OF ENDOCRINOLOGY (2019)

Article Gastroenterology & Hepatology

Bile acids drive colonic secretion of glucagon-like-peptide 1 and peptide-YY in rodents

Charlotte Bayer Christiansen et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2019)

Review Endocrinology & Metabolism

A review of dipeptidyl peptidase-4 inhibitors. Hot topics from randomized controlled trials

Carolyn F. Deacon

DIABETES OBESITY & METABOLISM (2018)

Article Endocrinology & Metabolism

Semaglutide versus dulaglutide once weekly in patients with type 2 diabetes (SUSTAIN 7): a randomised, open-label, phase 3b trial

Richard E. Pratley et al.

LANCET DIABETES & ENDOCRINOLOGY (2018)

Article Cell Biology

Anti-obesity effects of GIPR antagonists alone and in combination with GLP-1R agonists in preclinical models

Elizabeth A. Killion et al.

SCIENCE TRANSLATIONAL MEDICINE (2018)

Article Endocrinology & Metabolism

Enteroendocrine K and L cells in healthy and type 2 diabetic individuals

Tina Jorsal et al.

DIABETOLOGIA (2018)

Review Endocrinology & Metabolism

Diabetes mellitus, a state of low bone turnover - a systematic review and meta-analysis

Katrine Hygum et al.

EUROPEAN JOURNAL OF ENDOCRINOLOGY (2017)

Article Endocrinology & Metabolism

Chylomicrons stimulate incretin secretion in mouse and human cells

Arianna Psichas et al.

DIABETOLOGIA (2017)

Article Endocrinology & Metabolism

Glucose-dependent insulinotropic polypeptide promotes lipid deposition in subcutaneous adipocytes in obese type 2 diabetes patients: a maladaptive response

Sravan K. Thondam et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2017)

Article Endocrinology & Metabolism

Glucagon and Amino Acids Are Linked in a Mutual Feedback Cycle: The Liver-α-Cell Axis

Jens J. Holst et al.

DIABETES (2017)

Article Gastroenterology & Hepatology

Cephalic phase secretion of insulin and other enteropancreatic hormones in humans

Simon Veedfald et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2016)

Article Biochemistry & Molecular Biology

The Extracellular Surface of the GLP-1 Receptor Is a Molecular Trigger for Biased Agonism

Denise Wootten et al.

Article Endocrinology & Metabolism

Endogenous GLP1 and GLP1 analogue alter CNS responses to palatable food consumption

Jennifer S. ten Kulve et al.

JOURNAL OF ENDOCRINOLOGY (2016)

Article Endocrinology & Metabolism

Mechanisms underlying glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 secretion

Frank Reimann et al.

JOURNAL OF DIABETES INVESTIGATION (2016)

Article Endocrinology & Metabolism

Renal extraction and acute effects of glucagon-like peptide-1 on central and renal hemodynamics in healthy men

Ali Asmar et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2015)

Review Medicine, Research & Experimental

Gut chemosensing mechanisms

Arianna Psichas et al.

JOURNAL OF CLINICAL INVESTIGATION (2015)

Article Biochemistry & Molecular Biology

A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents

Brian Finan et al.

NATURE MEDICINE (2015)

Review Pharmacology & Pharmacy

The design and discovery of lixisenatide for the treatment of type 2 diabetes mellitus

Mikkel Christensen et al.

EXPERT OPINION ON DRUG DISCOVERY (2014)

Article Endocrinology & Metabolism

Glucose-dependent Insulinotropic Polypeptide: Blood Glucose Stabilizing Effects in Patients With Type 2 Diabetes

Mikkel B. Christensen et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2014)

Article Multidisciplinary Sciences

The Role of SGLT1 and GLUT2 in Intestinal Glucose Transport and Sensing

Pia V. Roeder et al.

PLOS ONE (2014)

Article Endocrinology & Metabolism

Hindbrain GLP-1 receptor-mediated suppression of food intake requires a PI3K-dependent decrease in phosphorylation of membrane-bound Akt

Laura E. Rupprecht et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2013)

Article Gastroenterology & Hepatology

The effect of exogenous GLP-1 on food intake is lost in male truncally vagotomized subjects with pyloroplasty

Astrid Plamboeck et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2013)

Article Endocrinology & Metabolism

Calcium-sensing receptor (CaSR): Pharmacological properties and signaling pathways

Arthur D. Conigrave et al.

BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM (2013)

Review Endocrinology & Metabolism

Incretin hormones and the satiation signal

J. J. Holst

INTERNATIONAL JOURNAL OF OBESITY (2013)

Article Cell Biology

Unimolecular Dual Incretins Maximize Metabolic Benefits in Rodents, Monkeys, and Humans

Brian Finan et al.

SCIENCE TRANSLATIONAL MEDICINE (2013)

Article Biochemistry & Molecular Biology

Regulation of Adipocyte Formation by GLP-1/GLP-1R Signaling

Tenagne Delessa Challa et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

Article Endocrinology & Metabolism

2-Oleoyl Glycerol Is a GPR119 Agonist and Signals GLP-1 Release in Humans

Katrine B. Hansen et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2011)

Article Gastroenterology & Hepatology

Differential processing of pro-glucose-dependent insulinotropic polypeptide in gut

Yukihiro Fujita et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2010)

Review Endocrinology & Metabolism

GIP and GLP-1, the two incretin hormones: Similarities and differences

Yutaka Seino et al.

JOURNAL OF DIABETES INVESTIGATION (2010)

Article Biochemistry & Molecular Biology

Role of MGAT2 and DGAT1 in the release of gut peptides after triglyceride ingestion

Mayumi Okawa et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2009)

Article Endocrinology & Metabolism

Evidence that Intestinal Glucagon-Like Peptide-1 Plays a Physiological Role in Satiety

Diana L. Williams et al.

ENDOCRINOLOGY (2009)

Article Endocrinology & Metabolism

Arcuate glucagon-like peptide 1 receptors regulate glucose homeostasis but not food intake

Darleen A. Sandoval et al.

DIABETES (2008)

Review Gastroenterology & Hepatology

Biology of incretins: GLP-1 and GIP

Laurie L. Baggio et al.

GASTROENTEROLOGY (2007)

Article Endocrinology & Metabolism

Effects of PYY1-36 and PYY3-36 on appetite, energy intake, energy expenditure, glucose and fat metabolism in obese and lean subjects

Birgitte Sloth et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2007)

Article Endocrinology & Metabolism

Glucagon-like peptide 1 secretion by the L-cell - The view from within

Gareth E. Lim et al.

DIABETES (2006)

Article Biochemistry & Molecular Biology

Prohormone convertase 1/3 is essential for processing of the glucose-dependent insulinotropic polypeptide precursor

R Ugleholdt et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Article Pharmacology & Pharmacy

Pharmacokinetics, pharmacodynamics, and safety of exenatide in patients with type 2 diabetes mellitus

OG Kolterman et al.

AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY (2005)

Article Endocrinology & Metabolism

Neural regulation of glucagon-like peptide-1 secretion in pigs

L Hansen et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2004)

Article Physiology

Gastric distension induces c-Fos in medullary GLP-1/2-containing neurons

N Vrang et al.

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2003)

Article Endocrinology & Metabolism

Incretin secretion in relation to meal size and body weight in healthy subjects and people with type 1 and type 2 diabetes mellitus

T Vilsboll et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2003)

Article Biochemistry & Molecular Biology

Inhibition of gastric inhibitory polypeptide signaling prevents obesity

K Miyawaki et al.

NATURE MEDICINE (2002)

Article Endocrinology & Metabolism

GLP-1-(9-36) amide reduces blood glucose in anesthetized pigs by a mechanism that does not involve insulin secretion

CF Deacon et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2002)

Article Endocrinology & Metabolism

Exendin-4 reduces fasting and postprandial glucose and decreases energy intake in healthy volunteers

CMB Edwards et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2001)