期刊
FRONTIERS IN CARDIOVASCULAR MEDICINE
卷 7, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fcvm.2020.614279
关键词
aldosterone; mineralocorticoid receptor (MR); myocardial stretch; heart failure; NHE1; oxidative stress
资金
- Agencia Nacional de Promocion Cientifica y Tecnologica of Argentina [PICT2016-2289]
- CONICET [PIP2015-0750]
- [PICT2016-1964]
Current evidence suggests that cardiac mineralocorticoid receptor (MR) activation following myocardial stretch plays a crucial physiological role, while clinical evidence indicates a detrimental role in severe cardiac diseases like congestive heart failure. Recent discoveries on locally triggered cardiac MR signals shed light on its potential physiological and pathological consequences in the heart.
Current evidence reveals that cardiac mineralocorticoid receptor (MR) activation following myocardial stretch plays an important physiological role in adapting developed force to sudden changes in hemodynamic conditions. Its underlying mechanism involves a previously unknown nongenomic effect of the MR that triggers redox-mediated Na+/H+ exchanger (NHE1) activation, intracellular Na+ accumulation, and a consequent increase in Ca2+ transient amplitude through reverse Na+/Ca2+ exchange. However, clinical evidence assigns a detrimental role to MR activation in the pathogenesis of severe cardiac diseases such as congestive heart failure. This mini review is meant to present and briefly discuss some recent discoveries about locally triggered cardiac MR signals with the objective of shedding some light on its physiological but potentially pathological consequences in the heart.
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