期刊
COMMUNICATIONS BIOLOGY
卷 4, 期 1, 页码 -出版社
NATURE PORTFOLIO
DOI: 10.1038/s42003-020-01618-5
关键词
-
资金
- Support Program for Strategic Research Foundation at Private Universities 2012-2016 from Ministry of Education, Culture, Sports, Science, and Technology, Japan
- [23110003]
- [25293014]
- [20H03386]
- [25460080]
Researchers show that chondroitin 6-sulfate represses keratinocyte proliferation in skin and that mice deficient in chondroitin-6-O-sulfotransferase-1 (C6st-1) exhibit keratinocyte hyperproliferation and impaired skin permeability barrier. This study suggests that the expression level of C6st-1 may serve as a biomarker for susceptibility to psoriasis.
Chondroitin sulfates are implicated in epidermal biology, but functional significance of chondroitin sulfates remains unclear. Here, we report that chondroitin 6-sulfate is important for the maintenance of epidermal homeostasis. Mice deficient in chondroitin 6-O-sulfotransferase-1 (C6st-1), which is involved in biosynthesis of chondroitin 6-sulfate, exhibited keratinocyte hyperproliferation and impaired skin permeability barrier function. Chondroitin 6-sulfate directly interacted with the EGF receptor and negatively controlled ligand-induced EGF receptor signaling. Normal function of hyperproliferative C6st-1-knockout mouse-derived keratinocytes was rescued by treatment with exogenous chondroitin 6-sulfate. Epidermal hyperplasia, induced using imiquimod, was more severe in C6st-1-knockout mice than in C6st-1 wild-type mice. Taken together, these findings indicate that chondroitin 6-sulfate represses keratinocyte proliferation in normal skin, and that the expression level of C6st-1 may be associated with susceptibility to psoriasis. Kitazawa et al. show that chondroitin 6-sulfate represses keratinocyte proliferation in skin. They find that mice deficient in chondroitin-6-O-sulfotransferase-1 (C6st-1), which synthesizes chondroitin 6-sulfate, exhibit keratinocyte hyperproliferation and impaired skin permeability barrier. This study suggests that the expression level of C6st-1 may serve as a biomarker for the susceptibility to psoriasis.
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