4.6 Review

Statins: HMG-CoA Reductase Inhibitors as Potential Anticancer Agents against Malignant Neoplasms in Women

期刊

PHARMACEUTICALS
卷 13, 期 12, 页码 -

出版社

MDPI
DOI: 10.3390/ph13120422

关键词

statin therapy; anticancer activity; malignant neoplasms; breast cancer; endometrial cancer; ovarian cancer; cancer prevention; adjuvant chemotherapy

资金

  1. Polish Science Center (NCN) [2019/32/U/ST4/00092]
  2. Polish National Agency for Academic Exchange (NAWA) [PPN/BEK/2019/1/00034]
  3. Polish Ministry of Science and Higher Education (MNiSW) [STYP/15/1665/E-336/2020]

向作者/读者索取更多资源

Statins, also known as HMG-CoA inhibitors, are a class of bioactive small molecules that efficiently reduce the levels of cholesterol, and therefore are commonly used to manage and prevent various cardiovascular diseases. With respect to their original medical indications, statins are currently in the group of the most prescribed drugs worldwide. Of note is that statins are perceived actually rather as agents that have pleiotropic activities; in addition to their inhibitory activity on the production of endogenous cholesterol. Statins may also affect cell proliferation, angiogenesis and/or migration (metastasis) of different cancer cells, and play a positive role in the chemoprevention of cancer, thus being the excellent candidates to be repurposed in oncology. Particularly intriguing in this context seems to be the promising role of statins on both the incidence and course of common malignant neoplasms in women. In this article, we review and discuss the effect of the use of statins in the treatment of three types of cancer, i.e., breast, endometrial and ovarian cancer, with the highest mortality among gynecological cancers.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.6
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据