期刊
PHARMACEUTICALS
卷 14, 期 2, 页码 -出版社
MDPI
DOI: 10.3390/ph14020096
关键词
i-motif; DNA quadruplex structures; transcription regulation; cancer therapeutics
资金
- National Institutes of Health [P20GM121293]
The i-motif is a dynamic secondary DNA structure rich in cytosine, with potential as a molecular switch for gene expression control. It may play a role in facilitating or hindering expansion of DNA elements in genomic areas with repetitive nucleotide sequences. Recent discoveries, including the identification of a specific i-motif antibody, are advancing the field of i-motif research.
Stretches of cytosine-rich DNA are capable of adopting a dynamic secondary structure, the i-motif. When within promoter regions, the i-motif has the potential to act as a molecular switch for controlling gene expression. However, i-motif structures in genomic areas of repetitive nucleotide sequences may play a role in facilitating or hindering expansion of these DNA elements. Despite research on the i-motif trailing behind the complementary G-quadruplex structure, recent discoveries including the identification of a specific i-motif antibody are pushing this field forward. This perspective reviews initial and current work characterizing the i-motif and providing insight into the biological function of this DNA structure, with a focus on how the i-motif can serve as a molecular target for developing new therapeutic approaches to modulate gene expression and extension of repetitive DNA.
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