期刊
JOURNAL OF PERSONALIZED MEDICINE
卷 11, 期 1, 页码 -出版社
MDPI
DOI: 10.3390/jpm11010017
关键词
gamma oscillations; alcohol; tobacco; cannabis; cognition; co-morbidity
资金
- Brain and Behavior Research Foundation
- CIHR
- NIH, Brain Canada
- Temerty Family through the CAMH Foundation
- Campbell Research Institute
- Brainsway Ltd.
- Japan Agency for Medical Research and Development (AMED)
- TEIJIN PHARMA LIMITED
- Inter Reha Co., Ltd.
- Japan Health Foundation
- Meiji Yasuda Mental Health Foundation
- Mitsui Life SocialWelfare Foundation
- Takeda Science Foundation
- SENSHIN Medical Research Foundation
- Health Science Center Foundation
- Mochida Memorial Foundation for Medical and Pharmaceutical Research, Taiju Life SocialWelfare Foundation
- Daiichi Sankyo Scholarship Donation Program
- Magventure Inc.
- Rogue Resolutions Ltd.
- Miyuki Giken Co., Ltd.
Substance use disorders are a major public health problem, with over 200 million people reporting drug use in 2016. EEG can provide insights into the impact of SUDs on cognition, with different substances affecting gamma activity modulation in different ways. Alcohol has the most complex relationship with gamma activity compared to other substances.
Substance use disorders (SUDs) are a major public health problem-with over 200 million people reporting drug use in 2016. Electroencephalography (EEG) is a powerful tool that can provide insights into the impact of SUDs on cognition. Specifically, modulated gamma activity may provide an index of the pathophysiology of SUDs. Thus, the purpose of this review was to investigate the impact of alcohol, tobacco, cannabis, cocaine, and amphetamine on gamma activity, among pre-clinical and clinical populations during acute and chronic exposure and withdrawal states. We searched multiple databases for key terms related to SUDs, EEG, and gamma and ensured rigorous methods by using a standardized review reporting tool. We included 30 studies in this review and found that all substances were associated with modulation of gamma activity, across states and in both preclinical and clinical populations. Gamma oscillations appeared to be differentially modulated in clinical versus preclinical populations and had the most complex relationship with alcohol, indicating that it may act differently than other substances. The findings of this review offer insights into the pathophysiology of SUDs, providing a potential window into novel treatments for SUDs via modulation of gamma activity.
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