Proteotoxicity: A Fatal Consequence of Environmental Pollutants-Induced Impairments in Protein Clearance Machinery

A tightly regulated protein quality control (PQC) system maintains a healthy balance between correctly folded and misfolded protein species. This PQC system work with the help of a complex network comprised of molecular chaperones and proteostasis. Any intruder, especially environmental pollutants, disrupt the PQC network and lead to PQCs disruption, thus generating damaged and infectious protein. These misfolded/unfolded proteins are linked to several diseases such as Parkinson's disease, Alzheimer's disease, Huntington's disease, and cataracts. Numerous studies on proteins misfolding and disruption of PQCs by environmental pollutants highlight the necessity of detailed knowledge. This review represents the PQCs network and environmental pollutants' impact on the PQC network, especially through the protein clearance system.

Automated summary

The tightly regulated protein quality control system functions through a network of molecular chaperones and proteostasis to maintain the balance between correctly folded and misfolded proteins, but environmental pollutants can disrupt this system, causing protein damage and diseases. It is increasingly recognized that detailed knowledge concerning protein misfolding and disruption of the protein quality control system by environmental pollutants is crucial.