期刊
JOURNAL OF PERSONALIZED MEDICINE
卷 10, 期 4, 页码 -出版社
MDPI
DOI: 10.3390/jpm10040231
关键词
Alzheimer's; eye vascular network; choroid; retina; OCT; OCTA; Laguna ONhE; optic nerve head hemoglobin
资金
- Ophthalmological Network OFTARED of the Institute of Health of Carlos III of the Spanish Ministry of Economy [RD16/0008/0004, RD16/0008/0005]
- PN I +D +i 2008-2011
- ISCIII-Subdireccion General de Redes y Centros de Investigacion Cooperativa
- European programme FEDER
- Instituto de Salud Carlos III [PI09/90933]
- Spanish Ministry of Science, Innovation, and Universities [FPU17/01023]
- Complutense University of Madrid [CT42/18-CT43/18]
In Alzheimer's disease (AD), vascular changes could be caused by amyloid beta (A beta) aggregates replacing the contractile smooth musculature of the arteriole walls. These changes happen in the brain vascular network, but also in the eye, and are related to decreased vascular density and low blood flow. In patients with Alzheimer's disease, thinning of the choroid and the retina has been shown. The aim of this prospective study was to assess the retinal and choroidal vascular systems, analyzing the choroidal thickness with optical coherence tomography (OCT), the foveal avascular zone (FAZ) with OCT-angiography (OCTA), and the optic nerve head (ONH) hemoglobin with the Laguna ONhE program, to evaluate which of the two ocular vascular systems shows earlier changes in mild AD patients. These patients, compared to controls, showed a significantly thinner choroid at all the analyzed points, with the exception of the temporal macula (at 1000 and 1500 mu m from the fovea). On the other hand, the FAZ and ONH hemoglobin did not show significant differences. In conclusion, a thinner choroid was the main ocular vascular change observed in mild AD patients, while the retinal vessels were not yet affected. Therefore, choroidal thickness could be used an early biomarker in AD.
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