期刊
ISCIENCE
卷 24, 期 2, 页码 -出版社
CELL PRESS
DOI: 10.1016/j.isci.2021.102065
关键词
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资金
- National Natural Science Foundation of China [81873821, 82071605, 31625020, 31530045, 31830056, 31861163006, 81570759, 81270938]
- National Key Research and Development Program of China [2020YFA0509002, 2019YFA0802002, 2016YFC1305301]
- Chinese Academy of Sciences [XDB19020200, XDA16020200]
- Zhejiang Provincial Key Disciplines of Medicine (Innovation Discipline) [11-CX24]
- Fundamental Research Funds for the Central Universities [2020XZZX002-22]
- China Postdoctoral Science Foundation [2020TQ0260]
- Zhejiang Provincial Preferential Postdoctoral Foundation [ZJ2020150]
The study found that granulosa cells expressing Procr play a critical role in follicle development, possessing high proliferative capacity. Additionally, the increase in number of Procr granulosa cells is essential for follicle development.
Granulosa cells (GCs) play a critical role in folliculogenesis. It remains unclear how GCs expand during follicle development and whether there is a subpopulation of cells that is responsible for GCs growth. Here, we observed that a small population of GCs expressed stem cell surface marker Procr (Protein C receptor). Procr GCs displayed higher proliferation ability and lower levels of hormone receptors compared with Procr- GCs. Knockdown of Procr inhibited proliferation. Lineage tracing experiments demonstrated that they contribute to increasing numbers of GCs during folliculogenesis. Targeted ablation of Procr+ cells disrupted ovarian follicle development, leading to phenotypes of polycystic ovary syndrome. Our findings suggest that Procr-expressing GCs are endowed with high proliferative capacity that is critical for follicle development.
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