期刊
ISCIENCE
卷 24, 期 1, 页码 -出版社
CELL PRESS
DOI: 10.1016/j.isci.2020.101883
关键词
-
资金
- Japan Society for the Promotion of Science (JSPS) [18H02152]
- Grants-in-Aid for Scientific Research [18H02152] Funding Source: KAKEN
Beta-elemene has therapeutic effects on obesity-induced chronic inflammation by adjusting the balance of immune cell populations in fat tissue through the generation of regulatory T cells in the intestinal immune system by modulating DC function.
The role of the intestinal immune system in the inhibition of fat tissue-related inflammation by dietary material is yet to be elucidated. Oral administration of beta-elemene, contained in various foodstuffs, downregulated expressions of inflammatory cytokines and increased Foxp3(+)CD4(+) T cells in adipose tissue of obese mice. However, beta-elemene did not affect the inflammatory response of adipose tissue in vitro, suggesting that the inhibition observed in vivo was not due to direct interactions of adipose tissue with beta-elemene. Instead, beta-elemene increased Foxp3(+)CD4(+) T cell population enhancing gene expressions of transforming growth factor beta 1, retinaldehyde dehydrogenase 2, integrin alpha nu beta 8, and interleukin-10 in intestinal dendritic cells (DCs) in vivo and in vitro. Taken together, this study suggested the therapeutic effects of beta-elemene on treating experimental obesity-induced chronic inflammation by adjusting the balance of immune cell populations in fat tissue through the generation of regulatory T cells in the intestinal immune system by modulating DC function.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据