期刊
JOURNAL OF FUNGI
卷 7, 期 1, 页码 -出版社
MDPI
DOI: 10.3390/jof7010030
关键词
Aspergillus fumigatus; conidium; germination; asynchrony; transcriptome; aspergillosis
资金
- French national reference center for Primary Immunodeficiencies (CEREDIH, Hopital Necker-Enfants Malades, Paris, France)
- la Fondation pour la Recherche Medicale [DEQ20150331722 LATGE Equipe FRM 2015]
- CEREDIH
The germination of Aspergillus fumigatus is shown to be asynchronous, regardless of the nutritional environment and extensive gene deletions. The reasons for this asynchrony remain unknown, but it is essential for the completion of the biological cycle of this filamentous fungus.
Establishment of a fungal infection due to Aspergillus fumigatus relies on the efficient germination of the airborne conidia once they penetrate the respiratory tract. However, the features of conidial germination have been poorly explored and understood in this fungal species as well as in other species of filamentous fungi. We show here that the germination of A. fumigatus is asynchronous. If the nutritional environment and extensive gene deletions can modify the germination parameters for A. fumigatus, the asynchrony is maintained in all germinative conditions tested. Even though the causes for this asynchrony of conidial germination remain unknown, asynchrony is essential for the completion of the biological cycle of this filamentous fungus.
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